Status:
Ongoing
paper/report linked
Project number:
#12
Investigating events following SARS-CoV-2 infection
Investigating events following SARS-CoV-2 infection is an OpenSAFELY project from University of Bristol. Every time a researcher runs their analytic code against patient data, it is audited in public here.
Project Ongoing - paper/report linked
COVID-19 is associated with different symptoms. These symptoms usually go away within four weeks however, for some people, symptoms continue and new symptoms may develop. This is called post-COVID syndrome (or long COVID). Research to understand post-COVID syndrome is ongoing. Research has also shown that people with COVID-19 remain at elevated risk of health outcomes, such as heart attacks, up to a year after COVID-19. However, this research has mostly focused on cardiovascular disease, looked at a short time period after COVID-19, or has not considered whether people were vaccinated when they got COVID-19.
This project aims to address these gaps. We will investigate the rates of a broader range of outcomes in those with a COVID-19 diagnosis compared to those before or without a COVID-19 diagnosis in three cohorts. Our cohorts will differ by their vaccination status and the variant that people were likely exposed to - they are: the ‘pre-vaccination cohort’ (likely unvaccinated and likely exposed to wildtype or Alpha variants), the ‘vaccinated cohort’ (vaccinated and likely exposed to the Delta variant) and the ‘unvaccinated cohort’ (unvaccinated and likely exposed to the Delta variant).
Under this project, we have studied the following disease areas:
Cardiovascular (code) (publication)
Diabetes (code) (publication)
Mental health (code) (publication)
Gastrointestinal (code)
Autoimmune (code)
Work is ongoing for other disease areas under project 185.
Workspaces
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- GitHub repository:
- post-covid-autoimmune
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-autoimmune
- Git branch:
- Explore_study_def
- Created at:
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- GitHub repository:
- post-covid-autoimmune
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-diabetes
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-gastrointestinal
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-gi-bleeds
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-mentalhealth
- Git branch:
- rerun_dereg
- Created at:
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- GitHub repository:
- post-covid-diabetes
- Git branch:
- add-new-diabetes-analyses
- Created at:
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- GitHub repository:
- post-covid-gastrointestinal
- Git branch:
- fix-coxipw-error
- Created at:
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- GitHub repository:
- post-covid-gastrointestinal
- Git branch:
- fix-cox-ipw_3
- Created at:
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- GitHub repository:
- post-covid-gastrointestinal
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-gastrointestinal
- Git branch:
- table2-turn-off-main-analysis
- Created at:
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- GitHub repository:
- post-covid-bristol
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-cvd-methods
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-cvd-methods-redux
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-diabetes
- Git branch:
- make-diabetes-three-cohort-repo
- Created at:
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- GitHub repository:
- post-covid-gastrointestinal
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-gastrointestinal
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-mentalhealth
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-mentalhealth
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-mentalhealth
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-neurodegenerative
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-neurodegenerative
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-neurodegenerative
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-pre-vaccinated-cardiovascular
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-renal
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-renal
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-respiratory
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-respiratory
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-respiratory-incident-events
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-respiratory
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-unvaccinated
- Git branch:
- main
- Created at:
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- GitHub repository:
- post-covid-vaccinated
- Git branch:
- main
- Created at:
Project timeline
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Project created:
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Code first run:
Why is the code first run date before the project created date?
In OpenSAFELY Jobs, code is run within a workspace. The workspaces feature was introduced before the projects feature, meaning that in some cases, workspaces were created before projects.
Public repos
- post-covid-autoimmune
- post-covid-bristol
- post-covid-cvd-methods
- post-covid-cvd-methods-redux
- post-covid-diabetes
- post-covid-gastrointestinal
- post-covid-mentalhealth
- post-covid-neurodegenerative
- post-covid-pre-vaccinated-cardiovascular
- post-covid-renal
- post-covid-respiratory
- post-covid-respiratory-incident-events
- post-covid-unvaccinated
- post-covid-vaccinated
Private repos
These repos are currently not publicly visible
In accordance with the Principles of OpenSAFELY we expect all code from all users to be made public.
However, some GitHub repositories may be private during the development stage of a project, which means any links to them from this site will return a '404 Not Found' error unless you are logged in and have the relevant permissions.
Outputs
Researchers
- Alex Whitmarsh
- Elsie Horne
- Emily Eyles
- Emma Tarmey
- Genevieve Cezard
- Jose Ignacio Cuitun Coronado
- Kurt Taylor
- Marwa Al Arab
- Michael Gulley
- Rachel Denholm
- Rochelle Knight
- Scott Walter
- Venexia Walker
- Yinghui Wei